[PDF] Brain matrix: structure, turnover and necessity. | Semantic Scholar (2024)

The pathophysiological roles of the brain's ECM, particularly those of CSPGs, after neural insults are highlighted and how the ECM can be targeted to promote remyelination is discussed.

A new model is provided to explain the nature of glial diversity as an adaptive response to the extracellular milieu, and provide a different approach to understand the complex nature ofglia heterogeneity.

This review aims to summarize the multiple functions of proteoglycans with special emphasis on their intricate composition and the newly described signaling events in which these molecules play a key role.

Results showed that divisions of thalamus that relay information to cortical fields known rather for their plastic properties exibit a poor matrix immunoreactivity, whereas matrix accumulation is more enhanced in nuclei connected to primary cortical regions.

This chapter introduces the three types of ECM in the brain with a focus on the basem*nt membranes (BMs), and discusses BM changes in stroke.

This review will aid to understand how abnormal ECM remodeling contributes to remyelination failure in MS lesions and assists in developing therapeutic strategies to promote remYelination.

Recent advances in understanding of PNNs are discussed and how glial cells are central to ECM and PNN remodeling in normal and pathological states of the CNS are discussed.

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Fibulins are a newly recognized family of extracellular matrix proteins that share an elongated structure and many calcium-binding sites, owing to the presence of tandem arrays of epidermal growth factor-like domains.

Components of the extracellular matrix could provide valuable early information about the pathological state of the brain and their implication in different types of remodeling processes in adult brain, like normal and pathological synaptic plasticity, inflammatory and dementia-associated diseases and gliomas are indicated.

Current analysis of the molecular structures and substructures involved in hom*ophilic and heterophilic interactions of these molecules and complementary loss-of-function mutations might shed some light on the roles played by neurocan and interacting molecules in the fine tuning of the nervous system.

The present data suggest that Bral1 may play a pivotal role in the formation of the hyaluronan-associated matrix in the CNS that facilitates neuronal conduction by forming an ion diffusion barrier at the nodes.

It is proposed that HASs, which can retain HA on the cell surface, may act as a link between PNNs and neurons, and HAS and link proteins might be key molecules for PNN formation and stability.

The results suggest that brain link protein-1 may have distinct function from cartilage linkprotein-1 and play specific roles, especially in the adult brain, as well as suggest a possibility that brain links functions to stabilize the binding between hyaluronan and brevican.

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